Vitamin K and Biosynthesis of Protein and Prothrombin

Vitamin K and biosynthesis of protein and prothrombin.

The role of vitamin K in the synthesis of prothrombin has been examined with the following results. 1. Vitamin K deficiency has no effect on general protein synthesis as studied by amino acid incorporation into protein in vivo and in vitro and by tryptophan pyrrolase production following tryptophan feeding. 2. Prothrombin activity was found in normal rat liver microsomes with increased release ...

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Vitamin K and the Biosynthesis of Prothrombin

Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...

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Vitamin K and the Biosynthesis of Prothrombin

Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...

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Vitamin K and the Biosynthesis of Prothrombin V. -pCARBOXYGLUTAMIC ACIDS, THE VITAMIN K-DEPENDENT STRUCTURES IN PROTHROMBIN*

Tryptic peptides obtained from normal prothrombin have been compared with those obtained from prothrombin synthesized by cattle given the vitamin K antagonist dicumarol. Two peptides were found which contain vitamin K-dependent structures. These peptides contain residues 4 through 10 and residues 12 through 44, respectively. One of these (residues 4 through 10) has previously been shown to cont...

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Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.

Tryptic peptides obtained from normal prothrombin have been compared with those obtained from prothrombin synthesized by cattle given the vitamin K antagonist dicumarol. Two peptides were found which contain vitamin K-dependent structures. These peptides contain residues 4 through 10 and residues 12 through 44, respectively. One of these (residues 4 through 10) has previously been shown to cont...

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Vitamin K and Biosynthesis of Protein and Prothrombin

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